As I discovered when I tried playing FO4 the update broke the script extender and the mods I use in FO4. I was not a happy camper. But take heart, there's a way to undo the do. You have to have some patience and have a bit of software savvy but it's not difficult to roll back the update. Eventually, the script extender and all the mods will be updated to work with the FO4 Next Gen update. Just follow the video.
Good luck! Not that you'll need it, I'm sure.
To make it somewhat easier I've posted the first part of the instructions and the names of the 7 files you'll need to download from the steam download depot.
►►Many thanks to Playzftw7876!!!
How to open the Steam Console:
1. Navigate to your browser's address bar or Steam's address bar and enter this: "steam://nav/console"
2. Enter these depots, download each single one:
download_depot 377160 377162 5847529232406005096
download_depot 377160 377161 7497069378349273908
download_depot 377160 377163 5819088023757897745
download_depot 377160 377164 2178106366609958945
download_depot 377160 435870 1691678129192680960
download_depot 377160 435871 5106118861901111234
download_depot 377160 435880 1255562923187931216